PMC 7113207
maja 77, 4000 Kranj INTERSPAR IM 109 N
5.2.4 Ferroptosis suppressor protein 1 and coenzyme Q10 pathway FSP1 possesses NAD(P)H oxidoreductase activity and reduces CoQ to ubiquinol (CoQH2), which inhibits lipid peroxidation and ferroptosis by trapping lipid peroxidation free radicals (77, 78)
The most common adverse events reported were gastrointestinal (GI)-related, and those reported were of generally mild to moderate severity
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Drug-nave patients already exhibit disease-associated DNA-methylation differences in circulating T-cell subsets and synovial tissue, including global hypomethylation in early disease and cell-type-specific changes across nave and memory CD4+ lineages (119,120)
