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Trulicity 0.75 mg solution for injection in pre-filled pen Patient Information Leaflet

Formula: Concentration (mg/ml) = Powder amount (mg) Water volume (ml) Common scenarios: 50mg vial + 2.5ml water = 20mg/ml For 1mg dose: 1 20 = 0.05ml = 5 units on U-100 syringe For 2mg dose: 2 20 = 0.1ml = 10 units 50mg vial + 2ml water = 25mg/ml For 1mg dose: 1 25 = 0.04ml = 4 units For 2mg dose: 2 25 = 0.08ml = 8 units 100mg vial + 5ml water = 20mg/ml For 2mg dose: 2 20 = 0.1ml = 10 units For 3mg dose: 3 20 = 0.15ml = 15 units Use the peptide reconstitution calculator to verify your math before mixing

As class B1 peptide agonists engage their receptors via a two-domain interaction, their efficacy for G protein-mediated signalling is influenced by multiple factors, including the nature of interactions with the ECD and TMD, contributing to both peptide affinity and how ligandreceptor interactions influence G protein binding, nucleotide exchange and G protein dissociation from the receptor

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