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The weight loss produced by GLP-1 medications is genuine and clinically significant trials of semaglutide (Wegovy) have shown average weight loss of 15 to 20% of body weight over 68 weeks, which is comparable to the outcomes of bariatric surgery for many patients

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36 Currently, there is an ongoing randomized global phase 3 study to evaluate the impact of OCA on MASH with fibrosis (REGENERATE, NCT02548351) and on MASH with cirrhosis (REVERSE, NCT03439254), expected to be completed in 2022