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References: Cell Metabolism (2024)

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(4) Contraindications include conditions such as mechanical obstruction, asthma, coronary artery disease, hyperthyroidism, and epilepsy, where cholinergic stimulation may be harmful

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All other efforts ( i + 3 , i + 4 , Aib, etc.), including analogs with staples oriented at the hydrophobic interface, did not provide peptides with comparable activity