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This scientific term covers the bad things that happen, such as the death of a loved one, divorce, major changes in relationships, job loss, financial problems, workplace stress, childhood abuse, chronic illness, injury, moving, and transitioning into adulthood.[ref] Reduced sleep quality and quantity have strong links to major depressive disorder

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Oxidative stress, in turn, can activate inflammatory pathways, creating a feedback loop that perpetuates both oxidative damage and neuroinflammation