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La contraindicacin ms importante es la historia personal o familiar de carcinoma medular de tiroides (CMT) o el diagnstico de neoplasia endocrina mltiple tipo 2 (NEM-2) , un sndrome hereditario que aumenta el riesgo de varios tumores endocrinos, incluyendo CMT

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The cytosolic Ca 2+ response was determined as the change in GCaMP6s fluorescence (FGCaMP6s) from baseline to the maximum post-treatment value and the GCaMP6s area under the curve (AUC) was determined using GraphPad Prisim software