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J Adv Res 38:223244

14 H 22 CuN 6 O 4 GHK-Cu Mechanism of Action Chelates Cu in a square-pyramidal coordination geometry, with labile axial positions available for ternary-complex formation

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Although there are many reports that ME1 is very low or absent in mouse islets, there is a report that suppression of ME1 activity by 50% resulted in the reduction of GSIS by half [45], while overproduction of ME1 did not affect GSIS [46]