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Recent studies using GLP1R/GIPR dual agonists, especially the SURPASS clinical trials, have revealed beneficial effects of GIP activation when used in conjunction with GLP-1RAs

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These include: Age and overall health status Severity of Vitamin B12 deficiency Presence of underlying medical conditions, such as gastrointestinal disorders Concurrent medications that may interact with Vitamin B12 For example, older adults or those with severe deficiencies might need more

The researchers found that when the drug stimulated the brains central melanocortin system, the rat models lost body mass independent of a reduction in caloric intake