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Efficacy of soluble fibre, antispasmodic drugs, and gut-brain neuromodulators in irritable bowel syndrome: a systematic review and network meta-analysis

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"The positive ACHIEVE-1 results position orforglipron as a potential treatment option with meaningful A1C and weight reduction, and a safety profile similar to injectable GLP-1 therapies." Lilly and others are trying to develop oral therapies to complement current blockbuster drugs Novo Nordisk's Ozempic (semaglutide) and Lilly's dual GIP/GLP-1 agonist Mounjaro (tirzepatide) which are given by weekly injection to treat type 2 diabetes

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Leptin stimulates tissue inhibitor of metalloproteinase-1 in human hepatic stellate cells