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Notably, mechanistic studies employing chemogenetics, fiber photometry, and genetic knockout models have identified distinct neural circuits through which GLP-1R agonists exert their effects

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A recent study developed a new dual agonist combination of semaglutide and MK-801 (an NMDA antagonist-based antidepressant) to mitigate the known yo-yo effect of GLP-1RA [51]

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The preclinical literature reviewed herein consistently demonstrates that activation of the GLP-1 receptor system modulates multiple domains of psychostimulant-induced behavior, including acute locomotor activation, conditioned reward, self-administration, and reinstatement