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The antibodies on entering the CNS bind with the aquaporin 4 of the astrocytes, leading to activation of the classical complement pathway [137, 138]

It does this precisely by interacting with serotonin and melatonin

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70 The integration of finite element modeling and cadaveric studies offers a comprehensive view of the biomechanical impact of external loads on the ACL

Valproate was first used as an anticonvulsant to treat epilepsy but was subsequently discovered to also have mood-stabilising effects [177], which may be related to bipolar disorder and epilepsy sharing features, such as their episodic nature and being risk factors for one another [178]