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Purity, Testing, and Quality Verification HPLC and Mass Spectrometry Analysis Reversed-phase HPLC quantifies peptide purity by separating the main peak from synthesis-derived impurities

PMID: 30480966

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GLP-1 receptor agonists work by mimicking the glucagon-like peptide-1 hormone naturally produced in the gut after eating

Peer review Peer review information Nature thanks Mark Chiew, Sairam Geethanath and Kawin Setsompop for their contribution to the peer review of this work

This indicates that such side effects are uncommon but not negligible. Underreporting : The FAERS database relies on voluntary reporting, which means the actual incidence of these side effects could be higher due to underreporting. Comparative Risk : When compared to the general population or patients using other medications, the incidence of ear-related issues in GLP-1 RA users appears low