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The primary sources for this report include: Recalls (Enforcement Reports Database) The Food and Drug Administration (FDA) categorizes product recalls in its Enforcement Report database based on the level of health risk, labeling them as Class I, II, III, or not yet classified. While the database includes drugs, food, cosmetics, medical devices, biologics, tobacco, and veterinary products, this report only covers selected drug recalls

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podoplanin is a marker for soft tissue cancers, such as chondrosarcoma, and for lymphatic tumors, such as follicular dendritic cell sarcoma) (Xie et ai, 2008), and as PROXl has been implicated in predicting the invasiveness of colon cancer (Petrova et al., 2008), this emphasizes the use of the VEGFR2-blocking, human anti-VEGF antibodies of the invention to treat those particular disease indications

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