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Conclusion Four completed trials now confirm retatrutide's efficacy across different populations, doses, and durations: Phase 2 (338 patients, 48 weeks): 24.2% proof of concept TRIUMPH-4 (445 patients, 68 weeks): 28.7% first Phase 3 confirmation TRIUMPH-1 (2,339 patients, 80 weeks): 28.3% pivotal confirmation in general obesity population TRIUMPH-1 extension (subset, 104 weeks): 30.3% weight loss continues beyond 80 weeks TRANSCEND-T2D-1 (537 patients, 40 weeks): 16.8% weight loss and -2.0% HbA1c in type 2 diabetes The consistency between TRIUMPH-4 (28.7%) and TRIUMPH-1 (28.3%) across two very different populations is the most important finding for obesity it means the results aren't driven by population-specific factors, they reflect the drug's fundamental mechanism

This efficacy is likely due to tirzepatide's dual action on GIP and GLP-1 receptors, enhancing appetite suppression and energy expenditure

Int J Pharm 608:121039 Kluger AY, Mccullough PA (2018) Semaglutide and GLP-1 analogues as weight-loss agents

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Research efforts have focused on the regulation of the GLP-1R mediated signaling pathway as a therapeutic approach to type 2 diabetes (T2DM) and have resulted in the development of several GLP-1 FDA-approved agonists

Wang FY, Chi CC