Seek emergency medical care immediately for severe symptoms - persistent severe abdominal pain, vomiting that won't stop, signs of allergic reaction (swelling, difficulty breathing, rash), or symptoms of low blood sugar (shaking, sweating, confusion)
Metabolism (2018) 82:1117
Compounded semaglutide lacks the proprietary stabilizers found in brand-name products and is generally less tolerant of room temperature exposure
Plus there are more restrictions too
Many commercial plans require prior authorization, BMI documentation, and proof of comorbidities
A head-to-head clinical trial (SURMOUNT-5) published in The New England Journal of Medicine in 2025 also demonstrated the superiority of tirzepatide over semaglutide