Key findings across the STEP trials: Average weight loss of ~15% of body weight roughly 15 kg (33 lbs) for a 100 kg (220 lb) person 87% of patients lost at least 5% of body weight, compared to 31% on placebo Nearly 70% of patients lost at least 10% of body weight About 1 in 3 patients lost 20% or more Weight loss was maintained throughout the treatment period with continued medication use Significant improvements in blood pressure, blood sugar, cholesterol, and inflammatory markers alongside weight loss These results are dramatically better than any prior weight loss medication

More Serious Side Effects to Watch Out For: Pancreatitis (inflammation of the pancreas) Thyroid cancer (rare, but a concern, particularly with a family history) Gallbladder disease Kidney problems Low blood sugar, especially in people taking other diabetes medications Increased heart rate The FDA Endocrinologic and Metabolic Drugs Advisory Committee continues to evaluate these prescription drugs for long-term safety, particularly as more people use Ozempic to lose weight rather than for its original purpose
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Some reactions are uncommon but more serious
References Dalle Grave, R
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