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In parallel, drug developers running trials in frail and vulnerable cohorts with endpoints assessing muscle quality, strength, and functional performance will be valuable to position muscle preservation as an important differentiator in obesity therapy design

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NichollsSJBhattDLBuseJBPratoSDKahnSELincoffAMet alComparison of tirzepatide and dulaglutide on major adverse cardiovascular events in participants with type 2 diabetes and atherosclerotic cardiovascular disease: SURPASS-CVOT design and baseline characteristics