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Department of Agriculture Agricultural Research Service

In agreement with our immunoblotting analysis, we observed an induction of CHAC1 under cystine starvation in CHAC1 expressing H1299 cells but not those subject to CRISPR/Cas9-mediated CHAC1 knockout 48 , indicating antibody specificity (Supplementary Fig

Figure 1 The melanocortin receptors are modulated by several endogenous peptides, such as -, -, and -melanocyte stimulating hormone (MSH) and adrenocorticotropic hormone (ACTH), which are derived from proopiomelanocortin (POMC) precursors (29)

References 1 AlexievBAChouPMJenningsLJ

they are also known as nutrient-stimulated hormones

Finally, we will provide an overview of development considerations for future MC agonists and discuss where this mechanism of action fits into the larger obesity treatment landscape