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Topicals containing hydroquinone, alpha and beta hydroxy acids, tretinoin, mequinol, arbutin, vitamin C, soy extracts and concoctions of multiple ingredients, including newer cosmeceuticals, are now in vogue for treatment of facial melanoses especially melasma [1] and for general skin lightening, at least of the face, neck and other exposed parts

Neve, J

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Am J Perinatol

However, higher doses also come with an increased risk of side effects

During the acute phase of sepsis, glutathione synthesis is enhanced in the liver and other tissues, a process regulated by multiple factors, including a decreased reduced/oxidized glutathione ratio, reactive oxygen and nitrogen species, proinflammatory cytokines, heat shock proteins, and physical inactivity