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In terms of electrical remodeling, mitochondrial ROS decrease the activity of L-type Ca 2+ channels, resulting in a shortened action potential duration

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Hypoglycemic drugs such as metformin, SGLT2i, DPP-4i, GLP-1RA, anti-inflammation therapies, anti-senescence therapies, mineralocorticoid receptor antagonists, and stem cell therapies have also shown beneficial effects against tubular injury, potentially slowing the progression of the DKD, and thereby protecting the kidney

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