According to MHRA product information, constipation occurs in approximately 20% of patients taking higher doses for weight management, while rates are lower with diabetes doses
These metabolic differences are generally modest compared to the dramatic difference in total weight loss
A 2025 study presented at the Endocrine Societys annual meeting found that men with obesity or type 2 diabetes who used GLP-1 medications saw both significant weight loss and improved testosterone levels
Preclinical research in rodent models has consistently demonstrated that GLP-1 receptor activation reduces voluntary alcohol intake, decreases alcohol-seeking behaviour, and attenuates alcohol-induced dopamine release in reward centres of the brain
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Disruptions in BBSome assembly or function can impair receptor signaling, leading to the hallmark features of BBS