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The resulting histamine backlog causes widespread vasodilation (expanding of the blood vessels), leading to rapid drops in blood pressure

Tirzepatide activates both GLP-1 and GIP receptors, resulting in slightly higher constipation rates (2527% in trials) compared to semaglutide (1520%)

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Any papers resulting from these two trials do not appear to be indexed in major global databases like PubMed, and its not clear if they were ever published in peer-reviewed journals

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"They have to be markedly different to their natural form - which is tricky with peptides." Without a patent, he says, companies risk pouring money into a product with little financial protection