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[1] Additionally, the authors indicate that there is still a requirement for successful human trials to be completed prior to clinical translation as there are important differences between rodent and human physiology that could have a significant impact on the efficacy and safety of any agent

Obese mice exhibited lower baseline expression of 3-AR in both fat types compared to lean controls

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Bariatric Considerations: For obese patients, a 1-inch needle may only reach the adipose tissue, risking a subcutaneous deposition of an IM medication, which can alter absorption rates and cause severe tissue irritation