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Activation of Nrf2 leads to the upregulation of various antioxidant and detoxifying enzymes, enhancing the cellular defense against oxidative damage [213]

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Fulda S, Debatin K-M (2006) Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy

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Reference MK-677 Dosing Protocol MK-677 studies have applied the compound in doses of up to 25mg/daily for up to two years, while considerably shorter studies have also administered 50mg/daily [16, 20]

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