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The longest study on pineal peptides (Epithalamin) tracked subjects for 6 to 8 years with annual 10-day treatments

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Additionally, even though Nrf2 activation was seen in vivo , aldosterone-treated rat kidneys showed significant DNA damage, showing that the response was insufficient to shield the animals from these side effects (75)

Statistical study The findings were statistically analyzed using GraphPad Prism version 8