Altemose, N., Miga, K
However, the human relevance of fructose-induced gut leakiness and microbial dysbiosis is still controversial
Unlike the initial phase where doses increase gradually to minimize side effects, maintenance therapy aims to sustain metabolic benefits while balancing tolerabilitya balance that varies significantly between individuals based on genetic and biomarker factors
Heres an example of how the progression might look: Weeks 14 : 2.5 mg per week Weeks 58 : 5 mg per week Weeks 912 : 7.5 mg per week Weeks 1316 : 10 mg per week Weeks 1720 : 12.5 mg per week Week 21 and beyond : 15 mg per week, if necessary This gradual increase helps to minimize common side effects like nausea, vomiting, diarrhea, and abdominal discomfort
Hormonal profile and androgen receptor study in prepubertal girls with hypertrichosis
However, the agency says it cant rule out a small increase in risk because of the small total number of events in their surveillance systems, and its investigation is ongoing