When -synuclein reaches synaptic terminals, it causes templated misfolding of native neuronal -synuclein, allowing it to propagate trans-synaptically to linked neurons, similar to prion propagation
In addition, GSTs are also involved in conferring multidrug resistance with a non-catalytic mechanism through their inhibition of the JNK signaling pathway, an event that protects tumoral cells from apoptosis, as it will be detailed later
One study found that a 2% concentration of a glutathione cream improved the melanin index (a measure of melanin in skin) on dark spots when used twice a day for 10 weeks
G.FerriL.et al (2021)
doi:10.1016/j.ijpharm.2019.04.076 61
Signs you are ready to increase: Appetite suppression has noticeably decreased compared to earlier weeks at this dose Weight loss has stalled for 2+ weeks despite consistent diet and activity Gastrointestinal side effects from the current dose have resolved You have been at the current dose for at least 4 weeks Signs you should stay at your current dose longer: You are still losing weight consistently Appetite suppression remains effective You are experiencing ongoing nausea, vomiting, or fatigue Injection site reactions have not resolved Do not increase just because the schedule says to
