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Importantly a methyl block or methyl trapping can be a major cause of anxiety, depression, headaches, migraines and the like because methylfolate is being trapped and not able to be incorporated into the methionine cycle for use

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Cravo ML, Gloria LM, Selhub J, Nadeau MR, Camilo ME, Resende MP, Cardoso JN, Leitao CN, and Mira FC (1996)

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(yes) Thats why DSIP has so many non sleep effects like its ability to normalize blood pressure