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While SGLT2-i and GLP-1RA may offer additive or synergistic benefits in reducing BP and cardiovascular risk, current guidelines do not support their role as first-line antihypertensive agents or early adjunctive therapies over established agents such as thiazide diuretics, renin-angiotensin system (RAS) inhibitors, or calcium channel blockers (CCBs)
R.HolscherC.IrwinN.GaultV
As part of the trial, we did a mediation analysis to determine what is causing what
Its rapid responsiveness, ease of application, multi-target regulatory potential, low cost, and high efficacy offer clear advantages over conventional breeding and gene-editing approaches in terms of timeframe, expense, and applicability [16, 17]
Mutations in the SHANK3 gene are known to disrupt normal receptor binding in neurons and supportive glial cells called oligodendrocytes