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The study found that the effect of melatonin was not due to the melatonin receptors but rather acts in a receptor-independent manner to clear amyloid-beta plaque.[ref] In addition to clearing amyloid-beta plaque, another way that melatonin can protect against Alzheimers is through the reduction of ROS in the mitochondria in brain cells.[ref] This may be the key, rather than amyloid-beta clearance

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Colloids Surf B Biointerfaces 170:692700 Quintana M, Haro-Poniatowski E, Morales J, Batina N (2002) Synthesis of selenium nanoparticles by pulsed laser ablation