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According to the UK Summary of Product Characteristics, Rybelsus is not recommended in patients with severe gastrointestinal disease, including severe gastroparesis

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Genetic predispositions in GLP-1 pathway genes (GLP1R rs6923761, GIPR rs1800437, FTO rs9939609, MC4R rs17782313) may help contextualize expected medication response and guide dose selectionthough genetic testing does not replace clinical assessment or guarantee outcomes

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Prog Neurobiol (2011) 93(1):112

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