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While human studies remain scarce, emerging in vitro models simulating human gut conditions reveal variable microbiota responses to MPs, ranging from dysbiosis and inflammatory metabolite production to probiotic enrichment and metabolic adaptation (Fournier et al., 2023

Extended-release options, including Ritalin LA and Concerta, extend that to 6 to 12 hours depending on the formulation

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doi: 10.1111/j.1439-0272.2008.00837.x

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Yap SY, et al