No, Metformin will not increase blood pressure
High obesity prevalence (35%+) creates strong demand
While GLP-1 receptor agonists externally stimulate this pathway, the human body already possesses intrinsic mechanisms to regulate GLP-1 signaling through the gut microbiome
V.: The role of L-carnitine in the control of oxidative stress and lipid -oxidation during in vitro follicle growth, oocyte maturation, embryonic development and cryopreservation: A review, Zygote, 32, 335340, 2024
Studies also suggest they may reduce systemic inflammation and oxidative stress, two of the most significant drivers of aging
This protective mechanism served our ancestors well during famines but works against modern weight loss goals