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Identification of the exact mechanism for the lethal effect of silencing the enzyme requires further experiments, as do the effects of inhibitors, which are not necessarily solely due to loss of enzyme activity, because the inhibited enzyme may also have a gain of function leading to cell death [72]

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In August 2025, a review found that flavonoids, which contribute to bitter flavors in, say, citrus or hops, can stimulate GLP-1 release, too