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Additionally, GLP-1 inhibits the release of a hormone called glucagon from the pancreas, which reduces the liver's production of glucose

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1, 2027, representing reductions of approximately 50% and 35% for Wegovy and Ozempic, respectively, according to Novo Nordisk

48% discontinuation among weight loss GLP-1 users 33% discontinuation among diabetes GLP-1 users Discontinuation of GLP-1 therapy is associated with metabolic rebound, including weight regain, rising blood pressure, and worsening glycemic control, undermining both clinical outcomes and the value of initial investment

All regimens were associated with approximately 30% increased probability of achieving HbA1c target, 1 kg greater weight gain, and a borderline increase in the risk of severe hypoglycaemia

However, there have been safety concerns and warnings about counterfeit versions and compounded semaglutide products