Katkat et al, 2023
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Future progress requires standardized, well-powered RCTs, multi-compound synergistic formulations, and advanced CNS-targeted delivery platforms (e.g., nanoparticles, nanomicelles, NADES), alongside robust pharmacokinetics, dosage optimization, gutbrain axis evaluation, and safety characterization to translate these nutraceuticals into effective adjunctive neurotherapeutic regimens (49)
Sodium-glucose co-transporter-2 inhibitors with and without metformin: a meta-analysis of cardiovascular, kidney and mortality outcomes
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