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A formal description of the laminar flow rate of an incompressible, viscous fluid through a cylindrical tube, which is known as the Hagen-Poiseuille equation was independently proposed by Jean Lonard Marie Poiseuille (17971869) in 1838 (Poiseuille, 1838) and Gotthilf Heinrich Ludwig Hagen (17971884) in 1839 (Hagen, 1839
Preclinical studies in animal models, such as EAE and DSS-induced colitis, have consistently demonstrated the efficacy of targeting metabolic nodes like mTOR, AMPK, HIF-1, and PKM2 in rebalancing Th17/Treg responses