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The fourth component, GHK-Cu, will be voted on in a subsequent February 2027 meeting HHS has announced that GHK-Cu is expected to return to Category 1 (after being moved to Category 2 in September 2023), which would restore compounding access for injectable formulations. The recommendations of the PCAC are non-binding but noteworthy

Matrix breakdown involves the loss of key ECM components, including collagen and aggrecan, due to increased activity of matrix metalloproteinases and aggrecanases