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Apart from the modification and inactivation of antioxidant enzymes, simple amplification of ROS in the cytosol robs pheomelanin-containing cells of intracellular antioxidants, such as super oxide dismutase, leaving the cell susceptible to increased DNA damage (1)
Cell 92, 773784
Y.SongJ.BonaguidiM
Solis L, Behrens C, Bekele B, Ozburn N, Moran C, Minna J, Suraokar M, Stewart D, Swisher S , Corvalan A, Wistuba I
10.1038/s41598-022-24152-2 87 RosalA
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