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As estrogen levels decline, that support is withdrawn

When it happens, youll notice looser stools and more frequent trips to the toilet

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The reward circuit and related structures may participate in the interactions between the GLP-1 pathway and psychoactive substances, as GLP-1Rs are expressed in key brain regions like the ventral tegmental area (VTA) and the nucleus accumbens (NAc) that control reward behaviors [54]

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142 GLP-1 receptors in the mesolimbic system are implicated in the modulation of reward behavior, 143 whereas brain imaging studies document GLP-1-induced changes in brain regions related to appetite and reward, such as the insula, amygdala, putamen, and orbitofrontal cortex