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(Frontiers in Pharmacology, 2022) reported pharmacokinetics and tissue distribution in rats and dogs, including a rapid plasma half-life under 30 minutes after IM or IV dosing

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So, when these two are mixed, the fast a cid-base reaction occurs first, forming an ammonium salt, before any nucleophilic substitution reaction: Because of this, it is not practical to prepare an amide by direct reaction of a carboxylic acid and amines

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