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Dopamine supplementation would be evident, but this hydrophilic neurotransmitter does not cross the BBB and cannot enter the CNS due to brain endothelial tight junctions, active brain endothelial metabolism and lack of transporters [5]

Among all the engineered strains, the strain W303-1b/FGP with three biosynthetic pathways showed the highest GSH producing capacity and improved the intracellular GSH concentration by 2.19-fold compared with W303-1b (Table 3

Stolbov K, Hahn A, Benes B, Andel M, Treslov L

Diabetologia 2022;65:604619 [DOI] [PubMed] [Google Scholar] 209

Roles in Cell Cycle, Senescence, & Apoptosis GSH modulates key cellular processes, including proliferation, senescence, and apoptosis (1)