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A small uncontrolled open-label trial reported that receiving 120 mg pine bark extract, 60 mg vitamin C, and 30 IU vitamin E daily for 3 months in migraine patients led to a significant reduction in the headache frequency, severity, and migraine disability (91)

2 Chronic kidney disease poses a significant risk of kidney failure, cardiovascular events and death, 3 highlighting the critical need for research into its prevention and treatment