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Pharmacother J Hum Pharmacol Drug Ther 32(12):10951111 Gupta K, Zhang J (2005) Angiogenesis: a curse or cure

Interference of the p53-FOXO4 interaction resulted in selective apoptosis of senescent cells and restoration of tissue homeostasis in multiple mouse models

The increase in leg muscle mass translated to a significant increase in leg muscle strength by 1.0 kg for the L-Carnitine-combination Table 1 Demographics and characteristics of all randomized participants L-Carnitine-combination N= 14 L-Carnitine N= 14 Placebo N=14 PValue Age (Years) Mean SD 61.1 4.0 (14) 61.1 4.0 (14) 57.2 2.7 (14) 0.006 Gender [n (%)] Female 9 (64%) 8 (57%) 10 (71%) 0.919 Male 5 (36%) 6 (43%) 4 (29%) Alcohol Use [n (%)] Daily 2 (14%) 0 (0%) 0 (0%) 0.787 None 4 (29%) 3 (21%) 4 (29%) Occasionally 4 (29%) 6 (43%) 6 (43%) Weekly 4 (29%) 5 (36%) 4 (29%) Smoking Status [n (%)] Ex-Smoker 0 (0%) 4 (29%) 2 (14%) 0.138 Non-Smoker 14 (100%) 10 (71%) 12 (86%) Race [n (%)] American 0 (0%) 0 (0%) 1 (7%) 0.904 Eastern European White 1 (7%) 1 (7%) 0 (0%) North American Indian/Aboriginal 1 (7%) 0 (0%) 0 (0%) South American 1 (7%) 0 (0%) 1 (7%) Western European White 11 (79%) 13 (93%) 12 (86%) Ethnicity [n (%)] Hispanic or Latino 1 (7%) 0 (0%) 1 (7%) 1.000 Not Hispanic or Latino 13 (93%) 14 (100%) 13 (93%) Regularly Exercise [n (%)] No 9 (64%) 10 (71%) 5 (36%) 0.218 Yes 5 (36%) 4 (29%) 9 (64%) Weight Change in Past 3 Months [n (%)] Gain 2 (14%) 0 (14%) 0 (0%) 0.679 Loss 1 (7%) 1 (7%) 2 (14%) No Change 11 (79%) 13 (93%) 12 (86%) Weight (Kg) Mean SD 76.7 13.3 (14) 73.0 12.9 (14) 73.7 9.8 (14) 0.760 BMI (Kg/m2) Mean SD 27.71 2.75 (14) 25.92 3.06 (14) 26.57 2.56 (14) 0.241 N, number, SD standard deviation, Min minimum, Max maximum, n, number, %percentage Between-group comparison was made using ANOVA Between-group comparisons were made using Fishers Exact Test Supplement groups with differing letter superscripts are significantly different Probability values P0.05 are statistically significant Evans et al

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These four vitamins inherently possess antioxidant properties, allowing them to function as antioxidants (159, 160)