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Tirzepatide is a 39amino acid dual incretin receptor agonist that activates both GLP1 and GIP receptors, enhancing glucosedependent insulin secretion, suppressing glucagon, slowing gastric emptying, and reducing appetite [1] [2]

103,104 Besides, ME2 ablation results in elevated cellular ROS levels, which activates the AMPK pathway and then stimulates TP53 to attenuate melanoma cell proliferation

ClpP, a mammalian quality control protease, plays an important role in the initiation of the mitochondrial UPR, maintaining mitochondrial protein homeostasis [35]

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Pani MA, Regulla K, Segni M, Hofmann S, Hufner M, Pasquino AM, Usadel KH, Badenhoop K

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