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Description

Hyperpigmentation is a broad term that covers any form of skin darkening, such as post-acne marks, sun spots, and injury-related darkening

SIRT6 deacetylates PKM2 to suppress its nuclear localization and oncogenic functions

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10.1007/s10541-005-0248-3

This reversible modification acts like a protective shield, preventing these proteins from undergoing irreversible oxidation and permanent destruction