Considering this, it is imperative to comprehend the functional polymorphism and genetic variation, which might be the reason for gene duplication and diversification of GST gene family
J Biol Chem 286 , 1114111154, doi: 10.1074/jbc.M110.196543 (2011)
This, in turn, leads to reduced brain tryptophan concentration, decreased 5-HT levels, and diminished 5-HT receptor binding, which may underlie the 5-HT system dysfunction, impaired neurotransmission, and negative cognitive effects observed in SZ
Minton K
Further, increased ROS concentrations, associated with the pheomelanin, inhibits CD8+T cell function, indicated by reduced expression of CD3 as well as IFN- (66)
This behavior of the GS flux is caused by the competition between the higher inhibition of GS and GCL by GSH and the higher stimulation of GCL by estradiol [Figure 2]