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GLP-1 receptor agonists are also not recommended during breastfeeding, in line with UK SmPC advice for approved agents in this class

10.1021/jf00038a036 J Agric Food Chem

This indicates that the benefit depends on GLP-1 signaling itself, rather than on unrelated metabolic changes

The STEP (Semaglutide Treatment Effect in People with Obesity) trials, including over 4,500 participants, revealed that patients using Semaglutide 2.4 mg once weekly, alongside lifestyle changes, experienced meaningful weight loss over a 68-week period

Data were analyzed by 2-way ANOVA with Bonferronis post test or 2-tailed Students t test, as indicated

Module presence/absence matrix files will have the suffix presence-MATRIX.txt