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The intricacy and multidimensionality of the mechanisms underlying brain diseases demands such an adequate analytical and generalizing tool allowing taking into account the multifactorial nature of a brain disease, involvement of cross-signaling and interaction between different brain regions and peripheral organs and tissues [85].The principal cause of many brain diseases is insufficient insulin sensitivity (insulin resistance)

Side effects that persist beyond the adaptation period often respond to dose reduction

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LOX-1, the receptor for oxidized low-density lipoprotein identified from endothelial cells: implications in endothelial dysfunction and atherosclerosis