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doi:10.3389/fendo.2020.608733 4 Flanagan, J.L., Simmons, P.A., Vehige, J

IPA accumulation demonstrates biphasic mitochondrial regulation: acute exposure (30 min) enhances maximal mitochondrial respiratory capacity, while chronic exposure (24 h) significantly inhibits complexes I/II/IV activity and fatty acid oxidation, reducing oxygen consumption rates (Gesper et al., 2021)

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Based on this, a glycopolymer (GP) containing a caged hydrogen sulfide (H2S)/H2O2 dual-donor was synthesized to wrap GOx, aiming for complete depletion of tumor energy sources [155]